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Valerie L. O'Shea Murray, Ph.D.
Berwyn Office

1235 Westlakes Drive
Suite 200
Berwyn, PA 19312

P: 215-772-2215
F: 215-731-3771

Biography

Dr. Valerie L. O’Shea Murray is a patent agent in Montgomery McCracken’s Intellectual Property Department.

Valerie focuses on the preparation and prosecution of domestic and foreign patent applications. She provides litigation support in areas such as due diligence, freedom-to-operate, patentability analyses, and invalidity and non-infringement analyses. Valerie is experienced in chemical biology, enzymology, protein and nucleic acid biochemistry, biophysics, structural biology, and cellular biology.

Prior to joining Montgomery McCracken, Valerie worked at a boutique Intellectual Property firm based in Washington D.C.

Prior to working as a patent agent, Valerie was a NIH NRSA Postdoctoral Research Fellow for the department of Molecular and Cell Biology at University of California, Berkeley where she researched elucidating mechanisms of ATPase motors and switches involved in DNA replication initiation under Professor James Berger. Her research continued with Berger’s lab through its move to Johns Hopkins University’s department of Biophysics and Biophysical Chemistry, where she then became the Senior Research Specialist of her department.

Valerie conducted graduate research under Sheila David for the Department of Chemistry at the University of Utah, which consisted of mechanistic and structural investigations of a DNA repair Glycolase, MutY. This research exhibited that MutY utilizes a similar mechanism to retaining glycosidases for repairing oxidative DNA damage.

Selected Publications

Refereed Research Articles

  • Co authored, “Physical basis for the loading of a bacterial replicative helicase onto DNA,” Molecular Cell, 2019, 74(1), 173-184. E4.
  • Co-authored, “Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases,” Nucleic Acids Research, 2016, 44(2), 801-810.
  • Co-authored, “The bacterial DnaC helicase loader is a DnaB ring breaker,” Cell, 2013, 153, 438-448.
  • Co-authored, “Nucleotide and partner-protein control of bacterial replicative helicase structure and function,” Molecular Cell, 2013, 52, 844-854.
  • Co-authored, “Gas-phase studies of substrates for the DNA mismatch repair enzyme MutY,” Amer. Chem. Soc., 2012, 134, 19839-19850.
  • Co-authored, “Unnatural substrates reveal the importance of 8-oxoguanine for in vivo repair by MutY,” Nature Chemical Biology, 2008, 4, 51-58.
  • Co-authored, “Electron-trap for DNA-bound repair enzymes: A strategy for DNA-mediated signaling,” Proc. Natl. Acad. Sci. U.S.A., 2006, 103, 3610-3614.
  • Co-authored, “DNA-Bound Redox Activity of DNA Repair Glycosylases Containing [4Fe-4S] Clusters,” Biochemistry, 2005, 448397-8407.
  • Co-authored, “Protein-DNA Charge Transport: Redox Activation of a DNA Repair Protein by Guanine Radical,” Proc. Natl. Acad. Sci. U.S.A., 2005, 1023546-3551.

Refereed Review Articles

  • Co-authored, “Loading strategies of ring-shaped nucleic acid translocases and helicases,” Current Opinion in Structural Biology, 2014, 25C16-24.
  • Co-authored, “Base-excision repair of oxidative DNA damage,” Nature, 2007, 447, 941-950.

Academic Achievements

Valerie earned her Ph.D. and B.S. degree in Chemistry from the University of Utah.